| NMR RELAXIVITY AND IMAGING OF NEUTRAL MACROMOLECULAR POLYESTER GADOLINIUM(Ⅲ)COMPLEXES* |
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| 引用本文： | 叶朝辉.NMR RELAXIVITY AND IMAGING OF NEUTRAL MACROMOLECULAR POLYESTER GADOLINIUM(Ⅲ)COMPLEXES*[J].高分子科学,1999,0(5):471-475. |
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| 作者姓名： | 叶朝辉 |
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| 作者单位： | Laboratory of |
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| 基金项目： | Project supported by the Chinese Academy of Sciences and the State Sciences and Technology Commission of China. |
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| 摘 要： | Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.
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| 关 键 词： | Magnetic resonance imaging （MRI） Neutral contrast agent Macromolecular gadolinium complexes Relaxivity Acute toxicity |
| 收稿时间： | 1998-08-28 |
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