木脂素类化合物的全合成研究 |
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引用本文: | 潘鑫复,陈小川. 木脂素类化合物的全合成研究[J]. 有机化学, 2001, 21(11): 1060-1064 |
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作者姓名: | 潘鑫复 陈小川 |
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作者单位: | 兰州大学化学系, |
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基金项目: | 国家自然科学基金(Nos.29772012,29772015)资助项目. |
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摘 要: | 综述了本研究小组近几年在木脂素全合成研究中取得的新进展。主要包括三部分:通过β-酮酸酯偶联反应来合成去甲二氢愈创木酸及多种其它类型木脂素;通过氧化银偶联和DDQ合环首次合成黄酮木脂素(±)-Sinaiticin;通过Sharpless不对称双羟化为关键步骤首次手性合成1,4-苯并二氧六环类新木脂素。
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关 键 词: | 木脂素 去甲二氢愈创木酸 苯并 二氧六环P 黄酮木脂素 选择性 对映体 全合成 |
修稿时间: | 2001-08-06 |
Study on the total synthesis of lignan compounds |
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Affiliation: | Department of Chemistry, National Laboratory of Applied Organic. LActa Botanica Sini |
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Abstract: | This paper reviews progresses i total synthesis of lignans involving about twenty lignan compounds made by our research group over the last five years, which includes: 1) the total synthesis of nordihydroguaiautic acid and several other lignans by the coupling of β-keto esters, 2) the first synthesis of (±)-sinaiticin by coupling with silver oxide and cyclization with DDQ, and 3) an enantioselective synthesis approach to chiral 1, 4-benzodioxane lignans using Sharpless asymmetric dihydroxylation as a key step. |
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Keywords: | LIGNANS BENZO- DIOXANE P SELECTIVITY ENANTIOMORPH TOTAL SYNTHESIS |
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