一种多取代硝基环丙烷的开环反应研究

以一种多取代硝基环丙烷为底物,研究其在不同条件下的开环反应.以苄胺为亲核试剂时,底物发生开环生成烯胺化合物,对此反应机理进行了分析.研究了底物的还原开环反应：1）在Pd/C的催化氢化下,底物发生开环并消除硝基,得到烷基取代丙二酸二甲酯衍生物;2）在浓盐酸存在下用锌粉还原底物,得到五元环内酰胺.

Study on the Ring-opening Reactions of a Polysubstituted Nitrocyclopropane

Ring-opening reactions of a polysubstituted nitrocyclopropane under different conditions was studied. When the benzyl amine was used as nucleophile, ring-opening reaction of the substrate occurred and an enamine compound was obtained. The mechanism for the reaction was analyzed. The reductive ring-opening reaction of the substrate was also investigated： 1） By Pd/C catalytic hydrogenation, an aikyl-substituted dimethyl malonate derivative was obtained via nitro elimination and ring-opening of the substrate. 2） In the presence of concentrated hydrochloric acid, a lactam with a five-membered ring was acquired by reducing the cyclopropane with Zinc dust.