| 天然产物Haouamine A的全合成研究进展 |
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| 引用本文： | 刘升长,;李典鹏.天然产物Haouamine A的全合成研究进展[J].广州化学,2014(2):66-78. |
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| 作者姓名： | 刘升长 ;李典鹏 |
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| 作者单位： | [1]广西植物功能物质研究与利用重点实验室(广西植物研究所),广西桂林541006; [2]广西中医药大学药学院,广西南宁530001; [3]中国科学院广州生物医药与健康研究院,广东广州510530 |
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| 摘 要： | 回顾了Haouamine类化合物分离提取和结构鉴定,指出HaouamineA和Haouamine B区别在于茚环中的芳香环的氧化程度.Haouamine类化合物具有良好的抗肿瘤生物活性.综述了2003年至今HaouamineA全合成进展,特别总结了HaouaminA化合物的基本骨架和不对称合成研究,指出构建茚并四氢吡啶环中的二芳基季碳手性中心和高度张力的对环芳烷11元大环是合成的亮点,也是合成Haouamines类生物碱过程中难点.
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| 关 键 词： | Haouamine类化合物 全合成 天然产物 |
Advances on the Total Syntheses of Haouamines A |
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| Institution: | LIU Sheng-zhang , LI Dian-peng(1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, China; 2. University of Chinese Medicine in Guangxi, College of Pharmacy, Nanning 530001, China; 3. Guangzhou Institutes of Biomedicine and Health, The Chinese Academy of Sciences, The Science Park of Guangzhou 510530, China) |
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| Abstract: | The extraction, isolation and identification of Haouamines were reviewed. The difference between Haouamine A and Haouamine B was different oxidation degrees of indane ring. Haouamines showed potent biological activities against human colon carcinoma cells. The total synthesis of haouamine A reported from 2003 was reviewed. And the construction of basic skeleton and asymmetric synthesis of the Haouamin was emphasized. |
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| Keywords: | Haouamines total synthesis natural oroducts |
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