Poly(ethylene-glycol)-based fluorinated esters: a readily available entry for novel F-MRI agents |
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| Authors: | Sergio RossiMaurizio Benaglia Marco OrtenziEdoardo Micotti Carlo PeregoMaria Grazia De Simoni |
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| Institution: | a Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
b Istituto di Ricerche Farmacologiche Mario Negri, Via La Nasa 19, 20156 Milano, Italy |
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| Abstract: | Readily available, low cost, hydrosoluble poly(ethylene-glycol) derivatives of 2-(trifluoromethyl)-3,3,3-trifluoro-propanoic acid were easily synthesized and their properties as MRI agents are preliminarily investigated. Two novel polymers, of 2356 Da and 756 Da, respectively, both showing a single 19F signal at NMR in deuterated chloroform and D2O were fully characterized; both compounds were shown to be soluble in water. However when experiments of in vitro MR imaging were conducted a clear imaging was obtained only with the sample of 756 MW, pointing at the importance of the fluorine content of the carrier. |
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| Keywords: | Poly(ethylene-glycol) Magnetic resonance imaging Polymer 19F-NMR Fluorine |
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