A highly enantioselective intramolecular Heck reaction with a monodentate ligand. |
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| Authors: | Rosalinde Imbos Adriaan J Minnaard Ben L Feringa |
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| Affiliation: | Stratingh Institute, Department of Organic Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands. |
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| Abstract: | An efficient enantioselective intramolecular Heck reaction of cyclohexadienones, using readily available and modular TADDOL-based mono- and bidentate phosphoramidites as chiral ligands and not requiring any additives, has been developed. Excellent enantioselectivities up to 96% ee are reached for the first time in a Heck reaction with monodentate ligands. |
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