A practical synthesis of differentially protected 2-(hydroxymethyl)piperazines |
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| Authors: | Gao Hongwu Renslo Adam R |
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| Institution: | Pfizer Global Research and Development, 34790 Ardentech Court, Fremont, California 94555, USA. |
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| Abstract: | An efficient and scalable synthesis of three differentially protected 2-(hydroxymethyl)piperazines is presented, starting from optically active and commercially available (2S)-piperazine-2-carboxylic acid dihydrochloride. These synthetic building blocks are useful in the preparation of biologically active compounds and as chemical scaffolds for the construction of combinatorial libraries. |
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