Three-component synthesis of polysubstituted homoproline analogs |
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| Authors: | Kudryavtsev Konstantin V Irkha Veronika V |
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| Affiliation: | Department of Chemistry, Moscow State University, Lenin's Hills, Moscow, Russian Federation. kudr@org.chem.msu.su |
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| Abstract: | Tetrasubstituted pyrrolidines representing analogs of homoproline were synthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagine and N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configuration at the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale. |
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