Synthesis,Characterization and Biological Activity Studies on 6-<Emphasis Type="Italic">p</Emphasis>-Dimethylaminophenyl-5,6-dihydrobenzoimidazo[1,2-<Emphasis Type="Italic">c</Emphasis>]quinazoline: Crystal Structure of the Title Compound and Comparative Study with Related Derivatives |
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Authors: | S G Bubbly S B Gudennavar N M Nanje Gowda Rita Bhattacharjee V Gayathri S Natarajan |
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Institution: | (1) Department of Physics, Christ University, Hosur Road, Bangalore, 560029, Karnataka, India;(2) Dean of Science, Christ University, Bangalore, 560 029, Karnataka, India;(3) Department of Chemistry, Bangalore University, Central College Campus, Bangalore, 560001, Karnataka, India;(4) School of Physics, Madurai Kamaraj University, Madurai, 625021, Tamilnadu, India |
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Abstract: | Abstract Reaction of o-aminophenylbenzimidazole with p-dimethylaminobenzaldehyde yielded 6-p-dimethylaminophenyl-5,6-dihydrobenzoimidazo1,2-c]quinazoline, which was characterized by elemental analysis, IR, UV–Vis, 1H NMR, 13C NMR, mass spectral studies and X-ray crystal structure analysis. Studies on the antimicrobial activity of the compound revealed
that it is active against fungus Yeast but not Bacillus subtilis. The compound crystallized in the space group P21/n with the unit cell parameters a = 10.652(2) ?, b = 11.002(2) ?, c = 15.753(2) ?, β = 109.29(2)° and the structure was refined to an R-factor of 0.0479. The hydropyrimidine ring in the quinazoline moiety is in skew-boat conformation. The dimethylamino group
attached to phenyl ring is in conjugation with it. The structure was stabilized by intermolecular C–H–N interactions. A few
of the related quinazolines (6-p-hydroxyphenyl-5,6-dihydrobenzoimidazo1,2-c]quinazoline; 6-phenyl-5,6-dihydrobenzoimidazo1,2-c]quinazoline; 6-pyridyl-5,6-dihydrobenzoimidazo1,2-c]quinazoline; 6-furyl-5,6-dihydrobenzoimidazo1,2-c]quinazoline) were also examined for their biological activity, in addition to their characterization by IR, UV–Vis, 1H and 13C NMR spectral studies along with structural comparison. |
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