First natural urease inhibitor from Euphorbia decipiens |
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| Authors: | Ahmad Viqar Uddin Hussain Javid Hussain Hidayat Jassbi Amir Reza Ullah Farman Lodhi Muhammad Arif Yasin Amsha Choudhary Muhammad Iqbal |
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| Institution: | H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. vuahmad@cyber.net.pk |
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| Abstract: | Three new diterpene esters with a myrsinol-type skeleton have been isolated from Euphorbia decipiens BOISS. & BUHSE. The structure elucidation of the isolated compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear Overhauser effect spectroscopy (NOESY) experiments. Compounds 1 and 3 are active against prolyl endopeptidase and compound 2 showed inhibitory activity against urease enzyme. |
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