| 中药通心络对抑郁-动脉粥样硬化大鼠干预作用的血浆代谢组学研究 |
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| 引用本文： | 张凤霞,贾振华,戴伟东,高鹏,路鑫,吴以岭,许国旺.中药通心络对抑郁-动脉粥样硬化大鼠干预作用的血浆代谢组学研究[J].中国科学:化学,2010(6):725-732. |
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| 作者姓名： | 张凤霞 贾振华 戴伟东 高鹏 路鑫 吴以岭 许国旺 |
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| 作者单位： | [1]中国科学院大连化学物理研究所 中国科学院分离分析化学重点实验室,大连116023 [2]沈阳药科大学药学院,沈阳110016 [3]河北省中西医结合医药研究院,石家庄050035 |
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| 基金项目： | 科技部国家重点基础研究发展计划（2007CB914701＆2005CB523301）; 国际合作项目（2009DFA41250＆2006DFB32460）; 国家自然科学基金（20835006＆90709004）的资助 |
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| 摘 要： | 采用快速液相色谱串联离子阱飞行时间质谱(UFLC/MS-IT-TOF)技术对通心络干预下的抑郁-动脉粥样硬化大鼠的血浆代谢谱进行研究.结果表明,抑郁-动脉粥样硬化模型大鼠体内的氨基酸代谢、脂肪酸的β-氧化、胆固醇代谢及磷脂代谢发生了异常.中药通心络通过调节模型大鼠体内的色氨酸、苯丙氨酸代谢及某些胆汁酸的代谢,抑制大鼠抑郁-动脉粥样硬化的形成.该研究结果表明代谢组学在中药整体性药效评价、作用机理的阐明等方面具有很好的应用前景.
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| 关 键 词： | UFLC/MS-IT-TOF 抑郁-动脉粥样硬化 血浆 通心络 代谢组学 |
Plasma metabonomics study of depression-atherosclerosis rats treated with the traditional Chinese medicine Tongxinluo |
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| ZHANG FengXia,JIA ZhenHua,DAI WeiDong,GAO Peng,LU Xin,WU YiLing,＆ XU GuoWang.Plasma metabonomics study of depression-atherosclerosis rats treated with the traditional Chinese medicine Tongxinluo[J].Scientia Sinica Chimica,2010(6):725-732. |
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| Authors: | ZHANG FengXia JIA ZhenHua DAI WeiDong GAO Peng LU Xin WU YiLing ＆ XU GuoWang |
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| Institution: | 1 CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China 2 Department of Analytical Chemistry,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China 3 The Integration of Traditional and Western Medical Research Academy of Hebei Province,Shijiazhuang 050035,China |
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| Abstract: | A UFLC/MS-IT-TOF method is applied for plasma metabonomics study of depression-atherosclerosis rat model treated with the traditional Chinese medicine Tongxinluo.The results show that the abnormality of the amino acid metabolism,β-oxidation of fatty acid,cholesterol metabolism and lecithin metabolism occurred in the body of the model rat.The traditional Chinese medicine Tongxinluo regulates the metabolism of tryptophan,phenylalanine and some bile acids,finally inhibites the generation of depression-atherosclerosis.This study also shows that the metabonomics has a bright prospect in the efficacy evaluation and active mechanism elucidation of the traditional Chinese medicines. |
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| Keywords: | UFLC/MS-IT-TOF depression-atherosclerosis plasma Tongxinluo metabonomics |
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