| 微量热法在药物活性评价中的应用 |
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| 引用本文： | 胡艳军,蒋风雷,欧阳宇,刘义.微量热法在药物活性评价中的应用[J].中国科学:化学,2010(9):1276-1285. |
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| 作者姓名： | 胡艳军 蒋风雷 欧阳宇 刘义 |
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| 作者单位： | [1]病毒学国家重点实验室 生物医学分析化学教育部重点实验室 武汉大学化学与分子科学学院,武汉430072 [2]湖北师范学院化学与环境工程学院,黄石435002 |
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| 基金项目： | 国家自然科学基金（20803019 20873096＆20921062）; 湖北省教育厅科学技术研究计划（Q20082205）资助 |
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| 摘 要： | 围绕微量热法在药物研发、药物对微生物的抑制和抗菌药物筛选、中药基础理论,以及药物与生物大分子相互作用等方面的研究工作,初步总结了微量热方法在药物活性评价中的应用.
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| 关 键 词： | 微量热法 药物 活性评价 生物大分子 焓-熵补偿效应 |
Microcalorimetry in drug activity evaluation |
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| HU YanJun,JIANG FengLei,OUYANG Yu ＆ LIU Yi.Microcalorimetry in drug activity evaluation[J].Scientia Sinica Chimica,2010(9):1276-1285. |
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| Authors: | HU YanJun JIANG FengLei OUYANG Yu ＆ LIU Yi |
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| Institution: | State Key laboratory of Virology;Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education);College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China 2 College of Chemistry and Environmental Engineering,Hubei Normal University,Huangshi 435002,China |
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| Abstract: | Microcalorimetry has been found wide applications in drug activity evaluation in the last few years,particularly when drug discovery,microorganism inhibition and antimicrobial drugs screening,basic theory of traditional Chinese medicine,and drug interactions with biomacromolecules are under consideration.Recent progress in these fields is preliminarily reviewed. |
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| Keywords: | microcalorimetry drug activity evaluation biomacromolecule enthalpy-entropy compensation effect |
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