| 2-苯基-4-硒唑甲酸过渡金属配合物的合成、结构及生物活性研究 |
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| 引用本文： | 赵国良,施霞,张均平,刘建风,成会朵,邵邻相.2-苯基-4-硒唑甲酸过渡金属配合物的合成、结构及生物活性研究[J].中国科学:化学,2010(10):1525-1535. |
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| 作者姓名： | 赵国良 施霞 张均平 刘建风 成会朵 邵邻相 |
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| 作者单位： | [1]浙江省固体表面反应化学重点实验室 浙江师范大学物理化学研究所,金华321004 [2]浙江师范大学化学与生命科学学院,金华321004 |
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| 基金项目： | 浙江省自然科学基金（Y4080256）项目资助 |
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| 摘 要： | 合成了2-苯基-4-硒唑甲酸配体(HL)和相应的6个过渡金属配合物ML2(H2O)2](M=Co,Ni,Cu,Cd)1～4,ZnL2](5),CuL2(py)2](6).用元素分析、红外光谱、热重分析等表征手段确定了配合物的组成;用单晶X射线衍射测定了配合物3和6的结构;用溴化乙锭荧光探针初步研究了它们与DNA作用的强度和模式;考察了配体和配合物对大肠埃氏杆菌(E.coliJM109)、大肠杆菌(E.coli,DH5α)、表皮葡萄球菌(S.epidermidis)、金黄色葡萄球菌(S.aureus)、鲍曼不动杆菌(baumanii)、草绿色链球菌(S.viridans)6种细菌的抗菌活性及对正常细胞293T和肿瘤细胞RAW264.72的体外增殖抑制作用.
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| 关 键 词： | 2-苯基-4-硒唑甲酸 过渡金属 配合物 抗菌活性 抗肿瘤活性 |
Synthesis,crystal structures and biological activity of transition metal complexes of 2-phenyl-4-selenazole carboxylic acid |
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| ZHAO GuoLiang,SHI Xia,ZHANG JunPing,LIU JianFeng,XIAN HuiDuo,＆ SHAO LinXiang.Synthesis,crystal structures and biological activity of transition metal complexes of 2-phenyl-4-selenazole carboxylic acid[J].Scientia Sinica Chimica,2010(10):1525-1535. |
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| Authors: | ZHAO GuoLiang SHI Xia ZHANG JunPing LIU JianFeng XIAN HuiDuo ＆ SHAO LinXiang |
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| Institution: | 1 Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces,Institute of Physical Chemistry,Zhejiang Normal University,Jinhua 321004,China 2 College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua 321004,China |
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| Abstract: | 2-Phenyl-4-selenazole carboxylic acid （ HL ） and its six transition metal complexes ML2（H2O）2] （ M= Co,Ni,Cu,Cd） 1–4,ZnL2]（5）,CuL2（py）2]（6） were synthesized and characterized by elemental analysis,IR spectra,thermal analysis. Crystal structures of complexes 3 and 6 were determined by single-crystal X-ray diffraction method. The interaction between 7 compounds and DNA were studied by EtBr fluorescent probe. The antibacterial activity of 7 compounds against six species of bacteria which are E.coli JM109,E.coli,DH5α,S. epidermidis,S. aureus,baumanii,S. viridans were tested respectively. Also the inhibition of 7 componnds against normal cell 293T and tumor cell RAW 264.7 were tested. |
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| Keywords: | 2-phenyl-4-selenazole carboxylic acid transition metal complex antibacterial activity antitumor activity |
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