Functional oropharyngeal sensory disruption interferes with the cortical control of swallowing |
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Authors: | Inga K Teismann Olaf Steinstraeter Kati Stoeckigt Sonja Suntrup Andreas Wollbrink Christo Pantev Rainer Dziewas |
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Affiliation: | (1) Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Malmedyweg 15, 48149 Muenster, Germany;(2) Department of Neurology, University of Muenster, Albert-Schweitzer-Str. 33, 48149 Munster, Germany |
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Abstract: | Background Sensory input is crucial to the initiation and modulation of swallowing. From a clinical point of view, oropharyngeal sensory deficits have been shown to be an important cause of dysphagia and aspiration in stroke patients. In the present study we therefore investigated effects of functional oropharyngeal disruption on the cortical control of swallowing. We employed whole-head MEG to study cortical activity during self-paced volitional swallowing with and without topical oropharyngeal anesthesia in ten healthy subjects. A simple swallowing screening-test confirmed that anesthesia caused swallowing difficulties with decreased swallowing speed and reduced volume per swallow in all subjects investigated. Data were analyzed by means of synthetic aperture magnetometry (SAM) and the group analysis of the individual SAM data was performed using a permutation test. |
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