Cytotoxic lignans from the stems of Styrax camporum (Styracaceae) |
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Authors: | Teles Helder L Hemerly Jefferson P Paulettit Patrícia M Pandolfi José R C Araujot Angela R Valentini Sandro R Young M Claudia M Bolzani Vanderlan S Silva Dulce H S |
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Affiliation: | Instituto de Química - UNESP, Araraquara, C.P. 355, 14800-900. |
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Abstract: | An ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-)syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24h. Activities could be observed for egonol against C6 (IC50 = 3.2 microg/mL) and Hep-2 (IC50 = 3.6 microg/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 microg/mL) and HeLa (IC50 = 5.3 microg/mL) cells. |
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