Sequential oxidation/asymmetric aldol reaction of primary alcohols by resin-supported catalysts |
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| Authors: | Kengo AkagawaShota Takigawa Erika ManoKazuaki Kudo |
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| Institution: | Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan |
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| Abstract: | The sequential reaction including alcohol oxidation by TEMPO/Cu system and the asymmetric aldol reaction by peptide catalysis was realized using resin-supported catalysts. The step of oxidizing primary alcohols to the corresponding aldehydes could be dramatically enhanced through the introduction of triglycyl peptide to supported TEMPO and the method of pre-adsorbing a Cu-complex into resin beads. |
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| Keywords: | Sequential reaction Asymmetric aldol reaction Resin-supported catalyst TEMPO oxidation Peptide catalyst |
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