二维核磁共振波谱学-研究分子结构和动态的有力工具

今天的化学研究如果没有核磁共振是很难设想的。核磁共振对于探查溶液中的分子结构,研究固体材料以及分子动态已证明具有极丰富的信息来源。为了应付如此大量的信息,向二维谱扩展就成为很自然了。自从十二年前开始以来,二维谱已对下列几方面作出了贡献:用二维相关谱为解释偶合网络提供了许多有力的技术;用二维交叉弛豫谱测量核间距离;用二维交换谱研究化学交换网络。这些新的技术在化学及生物学中大分子的分析时往往难以理解。

TMO-DIMENSIONAL NMR SPECTROSCOPY:A POWERFUL TOOL FOR THE INVESTIGATION OF MEOLECULAR STRUCTURE AND DYNAMICS

Today chemical research is hardly conceivable without nuclear magnetic resonance.It has proved to be an exceedingly rich source of information for exploring the structure of molecules in solution, for the investigation of solid materials, and for the study of molecular dynamics. In order to cope with the over whelming information content, an extension to two-dimensional spectroscopy turned out to be indispensible. Two-dimensional spectroscopy has contributed, since its introduction 12 years ago a large number of new powerful techniques for the elucidation of coupling networks by 2D correlation spectroscopy,for the measurement of internuclear distances by 2D cross——relaxation spectroscopy, and for the investigation of chemical exchange networks by 2D exchange spectrosoc-py. These new techniques are particularly elusive for the analysis of large mol-ecules in chemistry and in biology.