A microbially based approach for the asymmetric synthesis of both enantiomers of R-and S-fluoxetine

Both enantiomers of fluoxetine were synthesized in five steps from ethyl benzoylacetate(1)using microbial-chemical approach with overall yields of 59% and 62% respectively.(S)-Enan-tiomer can be obtained in >99% e.e.by resting cell of baker's yeast and the R form was produced in 81 %e.e.by immobilized Geotrichum sp.G 38.

A microbially based approach for the asymmetric synthesis of both enantiomers of R- and S-fluoxetine

Both enantiomers of fluoxetine were synthesized in five steps from ethyl benzoylacetate ( 1 ) using microbial-chemical approach with overall yields of 59% and 62% respectively. (S)-Enantiomer can be obtained in >99% e.e. by resting cell of baker's yeast and the R form was produced in 81% e.e. by immobilized Geotrichum sp. G 38.