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Enantioseparation of flinderoles and borreverines by HPLC on Chirobiotic V and V2 stationary phases and by CE using cyclodextrin selectors |
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| Authors: | Jonathan P. Smuts Yun-Cheol Na Ravikrishna Vallakati Adam Přibylka Jeremy A. May Daniel W. Armstrong |
| Affiliation: | 1. Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX, 76019, USA 2. Seoul Center, Korea Basic Science Institute, 136701, Seoul, South Korea 3. Department of Chemistry, University of Houston, 136 Fleming Building, Houston, TX, 77204-5003, USA 4. Regional Centre of Advanced Technologies and Materials, Department of Analytical Chemistry, Palacky University, 17. Listopadu 12, 77146, Olomouc, Czech Republic |
| Abstract: | Racemic mixtures of the promising anti-malarial bisindole alkoids, flinderole A–C, desmethyl flinderole C, borreverine and isoborreverine, are baseline-separated for the first time by HPLC using vancomycin-based stationary phases and partially separated by capillary electrophoresis (CE) using cyclodextrin selectors. The HPLC results compare the performance of Chirobiotic V and V2 in the polar organic and reversed phase modes and their complementary selectivity is discussed. The performance of the cyclodextrin selectors in CE, while less effective, are discussed in terms of their selectivity in normal and reversed polarity modes. |
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