头孢唑酮与Triton X-100缔合体系的相互作用

抗生素头孢唑酮的加入使得非离子表面活性剂Triton X-100的表面活性降低. ¹H-NMR的结果表明，头孢唑酮增溶于胶束极性基团附近.头孢唑酮与Triton X-100胶束的结合常数随Triton X-100含量的增加而下降，但头孢唑酮在Triton X-100胶束相和水连续相之间的分配系数不随Triton X-100含量变化而变化.

Interaction of Cephanone with Triton X-100 Aggregates

The effects of cephanone on the surface activity and aggregation behavior of Triton X 100 molecule were studied by the methods of surface tension and fluorescence, respectively. The binding constant between cephanone and Triton X 100 micelles was determined by the method of steady state fluorescence. The location of cephanone in Triton X 100 micelles was investigated through nuclear magnetic spectroscopy(NMR). The results showed that the surface activity of Triton X 100 decreased with the increase of cephanone concentration. With the increase of Triton X 100 concentration, the binding constant between cephanone and Triton X 100 micelles decreased, but the distribution coefficient of cephanone between Triton X 100 micelles and water continuous phase kept to be invariable. The results of 1H NMR showed that cephanone was located around the polar group of Triton X 100 micelle.