Kinetics of hydroperoxyde-dependent naphthalene hydroxylation involving cytochrome P-450 of the intact and induced enzyme systems of rat liver microsomes |
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| Authors: | A A Akhrem S A Usanov S S Dvornikov and D I Metelitsa |
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| Institution: | (1) Institute of Bioorganic Chemistry, Belorussian Academy of Sciences, Minsk, USSR |
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| Abstract: | Hydroperoxide-dependent naphthalene hydroxylation involving rat liver microsomes has been studied. The direct interaction between cytochrome p-450 and cumyl hydroperoxide (CHP) has been demonstrated. Km values with respect to both the substrate and CHP have been determined using intact and induced enzyme systems. The nature of the hydroxylating agent and the possible role of high-valence iron in the processes of hydroxylation by microsomal systems is discussed.
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