Microwave Activated Solid Support Synthesis of New Antibacterial Quinolones |
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| Authors: | Mazaahir Kidwai Preeti Misra Bhavesh Dave Kumar R Bhushan Rajendra K Saxena Meena Singh |
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| Institution: | (1) Department of Chemistry, University of Delhi, Delhi-110007, India, IN;(2) Deparment of Microbiology, University of Delhi, South Campus, New Delhi-110021, India, IN |
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| Abstract: | Summary. A novel synthesis of 6-fluoro-7-(5-aryl-1,3,4-thiadiazol/oxadiazol-2-yl-sulfanyl)-4-quinolone-3-carboxylic acids from 7-chloro-6-fluoro-4-quinolone-3-carboxylic
acid and 5-substituted 1,3,4-thiadiazoles/oxadiazoles on basic alumina under microwave activation is described. All compounds
were screened for their in vitro antibacterial activity against B. lichenformis, 2689, K. aerogens 2281, S. typhimurium 2501, E. herbicola 2491, and P. vulgaris 2027 and found to possess activities comparable to that of the standard drug norfloxacin.
Received May 2, 2000. Accepted (revised) June 13, 2000 |
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| Keywords: | , ,Quinolones, Solid support, Microwave irradiation, Antibacterial activity, |
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