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Microwave Activated Solid Support Synthesis of New Antibacterial Quinolones
Authors:Mazaahir Kidwai  Preeti Misra  Bhavesh Dave  Kumar R Bhushan  Rajendra K Saxena  Meena Singh
Institution:(1)  Department of Chemistry, University of Delhi, Delhi-110007, India, IN;(2)  Deparment of Microbiology, University of Delhi, South Campus, New Delhi-110021, India, IN
Abstract:Summary.  A novel synthesis of 6-fluoro-7-(5-aryl-1,3,4-thiadiazol/oxadiazol-2-yl-sulfanyl)-4-quinolone-3-carboxylic acids from 7-chloro-6-fluoro-4-quinolone-3-carboxylic acid and 5-substituted 1,3,4-thiadiazoles/oxadiazoles on basic alumina under microwave activation is described. All compounds were screened for their in vitro antibacterial activity against B. lichenformis, 2689, K. aerogens 2281, S. typhimurium 2501, E. herbicola 2491, and P. vulgaris 2027 and found to possess activities comparable to that of the standard drug norfloxacin. Received May 2, 2000. Accepted (revised) June 13, 2000
Keywords:, ,Quinolones, Solid support, Microwave irradiation, Antibacterial activity,
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