Divergent total synthesis of the natural antimalarial marinoquinolines A, B, C, E and unnatural analogues |
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| Authors: | Cristiane Storck SchwalmCarlos Roque D. Correia |
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| Affiliation: | Instituto de Química, Universidade Estadual de Campinas, UNICAMP, 13084-917 Campinas, São Paulo, Brazil |
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| Abstract: | A new synthetic route to marinoquinolines was developed, allowing the synthesis of several structurally related compounds from a common key intermediate. Four natural marinoquinolines (A, B, C and E) and nine unnatural new analogues were prepared by this strategy, which features a Heck-Matsuda reaction in pure water and the Pictet-Spengler reaction as key steps. |
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| Keywords: | Marinoquinolines Antimalarial Heck-Matsuda reactions Pictet-Spengler |
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