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Highly enantioselective hydrogenation of new 2-functionalized quinoline derivatives |
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| Authors: | Anna M Maj Isabelle Suisse Catherine Méliet Christophe Hardouin |
| Institution: | a Université Lille Nord de France, F-59000 Lille, France b Université Lille1 Sciences et Technologies, F-59655 Villeneuve d’Ascq, France c ENSCL, CCM-CCCF, F-59652 Villeneuve d’Ascq, France d CNRS, UCCS UMR 8181, F-59655 Villeneuve d’Ascq, France e Oril Industrie, 13, rue Auguste Desgenétais, 76210 Bolbec, France |
| Abstract: | The asymmetric hydrogenation of a new series of 2-functionalized quinolines has been developed in the presence of in situ generated catalysts obtained from Ir(cod)Cl]2/(R)-bisphosphine/I2 combinations. The enantioselectivity levels were as high as 84-94% ee for the synthesis of 1,2,3,4-tetrahydroquinolines. |
| Keywords: | Asymmetric catalysis Hydrogenation Quinolines Iridium |
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