Synthesis of novel pyrazole derivatives incorporating one dicarba-closo-dodecaborane unit |
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| Authors: | Naiara Vá zquezVanessa Gó mez-Vallejo,Jordi Llop |
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| Affiliation: | Radiochemistry Department, CIC biomaGUNE, Paseo Miramón 182, San Sebastián 20009, Spain |
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| Abstract: | Boron clusters, and especially dicarba-closo-dodecaboranes, can be used as hydrophobic pharmacophores in the design of new drugs. In the current letter, analogs of the CB1 receptor inverse agonist Rimonabant incorporating a carborane cage (either ortho- or meta-carborane) have been synthesized in moderate yields and their structure has been elucidated by means of 1H NMR, 13C NMR, 11B NMR, and HPLC-MS. |
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| Keywords: | CB1 receptor Carborane Pyrazole |
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