Three-component sequential synthesis of N,N′-disubstituted 5-arylidenedihydropyrimidine-2,4-dione |
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| Authors: | Maria Cristina BellucciAlessandro Volonterio |
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| Institution: | a Dipartimento di Scienze Molecolari Agroalimentari, Università degli Studi di Milano, via Celoria 2, 20133 Milano, Italy
b Department of Chemistry, Materials and Chemical Engineer ‘Giulio Natta’, Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy |
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| Abstract: | A three-component sequential process consisting in (1) in situ formation of carbodiimides by Staudinger reaction, (2) reaction with 2-(bromomethyl)-3-aryl-2-propenoic acids, and (3) final cyclization of the resulting N-acylurea intermediates in order to obtain the synthesis of an array of N,N′-disubstituted 5-arylidenedihydropyrimidine-2,4-dione under mild conditions is presented. |
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| Keywords: | Multi-component Sequential synthesis Carbodiimides Dihydropyrimidine-2 4-dione N-Acylurea |
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