Fragmentation of protonated ions of peptides containing cysteine,cysteine sulfinic acid,and cysteine sulfonic acid |
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Authors: | Email author" target="_blank">Yinsheng?WangEmail author Shetty?Vivekananda Lijie?Men Qibin?Zhang |
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Institution: | Department of Chemistry, University of California at Riveirside, Riverside, California 92521-0403, USA. yinsheng.wang@ucr.edu |
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Abstract: | The oxidation of the sulfhydryl group in cysteine to sulfenic acid, sulfinic acid, and sulfonic acid in proteins is important in a number of enzymatic processes. In this study we examined the fragmentation of four peptides containing cysteine, cysteine sulfinic acid (Cys-SO(2)H), and cysteine sulfonic acid (Cys-SO(3)H) in an ion-trap mass spectrometer. Our results show that the presence of a Cys-SO(2)H in a peptide leads to preferential cleavage of the amide bond at the C-terminal side of the oxidized cysteine residue. The results are important for the determination of the site of the cysteine oxidation and might be useful for the sequencing of cysteine-containing peptides. |
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