Transformations of 5,6,7,8-tetrafluoro-2-ethoxycarbonylchromone under the action of primary amines |
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| Authors: | K. V. Shcherbakov Ya. V. Burgart V. I. Saloutin |
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| Affiliation: | (1) Postovsky Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, Yekaterinburg, 620041, Russia |
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| Abstract: | 5,6,7,8-Tetrafluoro-2-ethoxycarbonylchromone in aprotic polar solutions formed by nucleophilic aromatic ipso-substitution 7-alkyl(aryl)amino-5,6,8-trifluorochromones. This transformation in ethanol depended on the reactivity of the acting amine: with stronger nucleophiles, aliphatic amines, an opening of the γ-pyrone ring occurred, with aromatic amines 7-monosubstituted chromones were the main products, and the open-chain esters formed in lesser amount. |
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