Study of Polymorphism From DSC Melting Curves; Polymorphs of Terfenadine |
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| Authors: | Leit?o M L P Canotilho J Cruz M S C Pereira J C Sousa A T Redinha J S |
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| Institution: | (1) Departamento de Química, Faculdade de Cięncias e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal;(2) Faculdade de Farmácia, Universidade de Coimbra, 3000-295 Coimbra, Portugal |
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| Abstract: | Terfenadine samples prepared by crystallization in different media and supersaturation conditions were used to investigate
the polymorphism of the substance. The study was based on DSC melting curves. An empirical parametric equation was used for
modelling the experimental data. The signal recorded was resolved into the corresponding overlapping peak components by fitting
analysis. Four polymorphic phases were identified.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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| Keywords: | crystallization peak fitting polymorphism terfenadine |
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