Surface-enhanced Raman scattering for protein detection |
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Authors: | Xiao X Han Bing Zhao Yukihiro Ozaki |
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Institution: | (1) State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China;(2) Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo 669–1337, Japan |
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Abstract: | Proteins are essential components of organisms and they participate in every process within cells. The key characteristic
of proteins that allows their diverse functions is their ability to bind other molecules specifically and tightly. With the
development of proteomics, exploring high-efficiency detection methods for large-scale proteins is increasingly important.
In recent years, rapid development of surface-enhanced Raman scattering (SERS)-based biosensors leads to the SERS realm of
applications from chemical analysis to nanostructure characterization and biomedical applications. For proteins, early studies
focused on investigating SERS spectra of individual proteins, and the successful design of nanoparticle probes has promoted
great progress of SERS-based immunoassays. In this review we outline the development of SERS-based methods for proteins with
particular focus on our proposed protein-mediated SERS-active substrates and their applications in label-free and Raman dye-labeled
protein detection.
Figure Protein-mediated SERS-active substrates for protein detection |
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Keywords: | SERS Protein detection SERS-active substrate Label-free detection Raman dye-labeled detection |
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