Uncinoside A and B, two new antiviral chromone glycosides from Selaginella uncinata |
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Authors: | Ma Ling-Yun Ma Shuang-Cheng Wei Feng Lin Rui-Chao But Paul Pui-Hay Lee Spencer Hon-Sun Lee Song Fong |
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Affiliation: | Department of Chinese Materia Medica and Natural Products, National Institute for the Control of Pharmaceutical & Biological Products, Beijing, 100050 P. R. China. |
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Abstract: | Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC(50) value of 6.9 and 1.3 microg/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) with IC(50) value of 13.8 and 20.8 microg/ml, respectively. |
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