Synthesis of fused dihydro-pyrimido[4,3-d]coumarins using Biginelli multicomponent reaction as key step |
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Authors: | Mihaela Matache Cristian Dobrota Niculina D Bogdan Lavinia L Ruta Ileana C Farcasanu Daniel P Funeriu |
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Institution: | a Technical University of Munich, Department of Chemistry, Marie Curie Excellence Team, 4 Lichtenbergstr., 85747 Garching, Germany b University of Bucharest, Department of Chemistry, Division of Organic Chemistry, 90-92 Panduri Street, 050663, District 5, Bucharest, Romania |
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Abstract: | A new efficient approach for the synthesis of functionalized dihydro-pyrimido4,3-d]coumarins is described. Use of benzyl- or tert-butyl acetoacetate and various salicyl aldehydes in typical Biginelli multicomponent reactions provides esters that can be easily deprotected to yield the corresponding hydroxy acids. Annelation of the latter leads to the target dihydro-pyrimido4,3-d]coumarins. Formation of some unexpected oxo-bridged tetrahydro-pyrimidines is also described. Spectral properties of the synthesized dihydro-pyrimido4,3-d]coumarins indicate the necessity to revisit some compounds previously reported as products of direct one-pot Biginelli condensation involving 4-hydroxycoumarin as dicarbonyl component. |
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