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Regioselective synthesis of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton: a new class of compound |
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| Authors: | Gani Koza Ertan ?ahin |
| Affiliation: | a Department of Chemistry, Middle East Technical University, 06531 Ankara, Turkey b Department of Chemistry, Abant ?zzet Baysal, 14280 Bolu, Turkey c Department of Chemistry, Atatürk University, 25240 Erzurum, Turkey |
| Abstract: | We hereby report the first preparation of the 3,4-dihydrofuro[3,2-d]pyrimidin-2(1H)-one skeleton formed by two controlled Curtius rearrangements of the corresponding acyl azides, prepared from 2-(2-methoxy-2-oxoethyl)furan-3-carboxylate via the hydrazide. Rearrangement of the acyl azides followed by trapping by nucleophiles and intramolecular trapping provided the target compounds. |
| Keywords: | Pyrimidinone Furopyrimidinone Acyl azide Acyl hydrazide Curtius rearrangement |
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