Highly enantioselective Michael addition of acetone to nitroolefins catalyzed by chiral bifunctional primary amine-thiourea catalysts with acetic acid |
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| Authors: | Qing Gu |
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| Institution: | Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Highly enantioselective Michael reaction of acetone with a variety of nitroolefins catalyzed by N-(1R,2R)-2-aminocyclohexyl]-N′-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)-thiourea (1b) together with acetic acid is described. The Michael addition products were obtained in high yields (76-94%) and up to 96% ee. |
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