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Three-component synthesis of 2-imino-1,4-benzoxazines
Authors:Ma. Carmen Garcí  a-Gonzá  lez,Rosa Santillan,José   Manuel Mé  ndez-Stivalet
Affiliation:a Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina Iztapalapa, México D.F. 09340, Mexico
b Departamento de Química, Centro de Investigación y de Estudios Avanzados del IPN, Apdo. Postal 14-740, México D.F. 07000, Mexico
c Facultad de Química, Departamento de Química Orgánica, Universidad Nacional Autónoma de México, México D.F. 04510, Mexico
Abstract:A series of 2-imino-1,4-benzoxazines (8a-e) were prepared by the one-pot, three-component, condensation of salicylaldehyde (4), various ortho-aminophenols (5), and 2,6-dimethylphenylisonitrile (6). The structures of four of the crystalline benzoxazine derivatives (8b-e) were unambiguously established by X-ray analysis.
Keywords:2-Imino-1,4-benzoxazines   Imine   Multicomponent reactions
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