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Torrubiellutins A-C, from insect pathogenic fungus Torrubiella luteorostrata BCC 12904
Authors:Pattama Pittayakhajonwut  Atit Usuwan  Chakapong Intaraudom  Punsa Khoyaiklang  Sumalee Supothina
Institution:National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Paholyothin Road, Klong Luang, Pathumthani 12120 Thailand
Abstract:Investigation of the insect pathogenic fungus Torrubiella luteorostrata led to the isolation of three new macrocyclic torrubiellutins A-C (1-3) and the known pyrone diterpene 4. Structures were elucidated by spectroscopic data including 1D, 2D NMR, and MS spectral data. The absolute stereochemistry was determined by chemical means using Mosher reactions and Marfey's reagent, together with NOESY spectral data. Torrubiellutin C showed biological activities against KB, MCF-7, NCI-H187, and Vero cell lines with IC50 varying from 0.78 to 4.36 μg/mL, while compound 4 exhibited antimalaria and anti-inflammatory activity with IC50 values of 3.49 and 1.21 μg/mL, respectively.
Keywords:Torrubiella luteorostrata  Macrocyclic compounds  Torrubiellutin  Pyrone diterpene  Antimalarial  Anti-inflammatory
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