General and efficient synthetic approach to novel tricyclic spiroketones |
| |
| Authors: | Guo-Hua Chu Bertrand Le Bourdonnec Minghua Gu Christopher T Saeui Roland E Dolle |
| |
| Institution: | Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, United States |
| |
| Abstract: | A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
