Chemoselective functionalization of α-carbolines at the C-2, C-3, C-4, and C-6 positions using Suzuki-Miyaura reactions |
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| Authors: | Cédric Schneider Benoît Joseph |
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| Institution: | a Université de Lyon, Laboratoire Chimie Organique 2—Glycochimie, ICBMS, CNRS, UMR-5246, Université Claude Bernard—Lyon 1, Bâtiment Curien—CPE Lyon, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne, France
b Université de Lyon, Laboratoire Chimie Organique 1, ICBMS, CNRS, UMR-5246, Université Claude Bernard—Lyon 1, Bâtiment Curien—CPE Lyon, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne, France |
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| Abstract: | The synthesis of 2-, 3-, 4-, and 6-substituted pyrido2,3-b]indoles (α-carbolines) by palladium-catalyzed cross-coupling reactions from the corresponding halopyrido2,3-b]indoles is described. A sequential and a one-pot chemoselective double Suzuki-Miyaura coupling route is presented for the synthesis of symmetrically and unsymmetrically disubstituted pyrido2,3-b]indoles. |
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