Rearrangement of N-alkyl 1,2-amino alcohols. Synthesis of (S)-toliprolol and (S)-propanolol |
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| Authors: | Bé ranger Duthion,Janine Cossy |
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| Affiliation: | Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France |
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| Abstract: | N-alkyl 1,2-amino alcohols were rearranged stereospecifically by using TFAA/Et3N. This rearrangement has been used to synthesize N-isopropyl-3-(aryloxy)-2-hydroxypropylamines, β-adrenergic blocking agents such as (S)-toliprolol and (S)-propanolol. |
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| Keywords: | Rearrangement 1,2-Amino alcohols Aziridinium (S)-Propanolol (S)-Toliprolol |
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