Thio acid/azide amidation: an improved route to N-acyl sulfonamides |
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| Authors: | Barlett Kristin N Kolakowski Robert V Katukojvala Sreenivas Williams Lawrence J |
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| Institution: | Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA. |
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| Abstract: | STRUCTURE: SEE TEXT] A one-pot procedure for the conversion of carboxylic acids to N-acyl sulfonamides, via thio acid/azide amidation, is presented. The method is compatible with acid- and base-sensitive amino acid protection. N-Acyl sulfonamide synthesis on solid support, peptide thio acid/sulfonazide coupling, and N-alkyl amide synthesis via selective cleavage of sulfonyl from an N-alkyl-N-acyl sulfonamide are also reported. |
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