A facile synthesis of novel 9-substituted 2,3,4,9-tetrahydro-1H-xanthen-1-ones |
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| Authors: | Dariusz Deredas Bartosz Łągiewka Waldemar Maniukiewicz |
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| Institution: | 1. Institute of Organic Chemistry, Lodz University of Technology, ?eromskiego 116, 90-924 ?ód?, Poland;2. Institute of General and Ecological Chemistry, Lodz University of Technology, ?eromskiego 116, 90-924 ?ód?, Poland |
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| Abstract: | A strategically new approach to 9-substituted 2,3,4,9-tetrahydro-1H-xanthen-1-ones is described. The protocol includes TMG promoted, conjugate addition of cyclohexane-1,3-diones to 3-(diethoxyphosphoryl)coumarins and a domino transesterification-cyclodehydration reaction of the adducts obtained. Modification of the tetrahydroxanthenone at position 9 is reported for the first time. |
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| Keywords: | Michael addition HWE olefination 1 1 3 3-Tetramethylguanidine Cyclohexane-1 3-diones Coumarins Tetrahydroxanthenones |
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