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Catalytic and metal-free intramolecular hydroalkoxylation of alkynes |
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| Authors: | Alexandre Jean Jacques Rouden Jacques Maddaluno Michaël De Paolis Jérôme Blanchet |
| Affiliation: | 1. Normandie Université, ENSICAEN, UNICAEN, CNRS, Laboratoire LCMT (UMR 6507 & FR 3038), 14000 Caen, France;2. Normandie Université, UNIROUEN, INSA de Rouen, CNRS, Laboratoire COBRA (UMR 6014 & FR 3038), 76000 Rouen, France |
| Abstract: | Benzyltrimethylammonium hydroxide act as an efficient metal-free catalyst for the intramolecular hydroalkoxylation of alkynes. Notably, the use of microwave irradiation allowed reaction to operate in only two minutes. Under optimized reaction conditions, linear alkynes bearing aryl and heteroaryl substituents were successfully cyclized with good level of stereoselectivity. |
| Keywords: | Hydroalkoxylation Cyclization Alkynes Enol ether Microwave-assisted synthesis |
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