An ESIPT-based fluorescent probe for Hg2+ in aqueous solution and its application in live-cell imaging |
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| Authors: | Jun Tang Hui Wu Shuai Yin Yifeng Han |
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| Institution: | Department of Chemistry, Engineering Research Center for Eco-Dyeing & Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, China |
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| Abstract: | A new Excited-State Intramolecular Proton Transfer (ESIPT) based fluorescent probe for the detection of Hg2+ has been rationally designed and developed. Based on the specific reactivity of mercury-promoted hydrolysis, the probe exhibits high selectivity and sensitivity for mercury ions in almost pure aqueous solution (containing only 1% DMSO) with a low detection limit of 1.9?ppb. Furthermore, the probe was also successfully used for fluorescence imaging of Hg2+ in live cells. |
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| Keywords: | Fluorescent probe ESIPT-based Mercury ions Live-cell imaging 3-Hydroxyphthalimide |
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