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N-Alkylation of Pyrazoles with Mannich Bases Derived from ortho-Hydroxyacetophenones |
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| Authors: | Gh Roman E Comanita B Comanita |
| Institution: | (1) Chemistry Department, Transilvania University, RO-2200 Brasov, Romania;(2) Department of Organic Chemistry, Gh. Asachi Technical University, RO - 6600 IASI, Romania;(3) Institute for Chemical Process and Environmental Technology, National Research Council of Canada, KIA, OR6, Ottawa, Canada |
| Abstract: | The involvement of Mannich bases derived from ortho-hydroxyacetophenones in amine-exchange reactions with pyrazole and methyl- and/or halogen-substituted pyrazoles was studied. The corresponding  -(pyrazol-1-yl)ethyl ketones resulted in excellent yield and were characterized by elemental analysis, IR, and 1H and 13C NMR spectroscopy. |
| Keywords: | Mannich bases pyrazole N-alkylation ortho-hydroxyacetophenones |
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