Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Regulation of stearoyl-CoA desaturase-1 after central and peripheral nerve lesions

Authors:	Email author" target="_blank">Sebastian?Breuer Email author Katrin?Pech Armin?Buss Christoph?Spitzer Juris?Ozols Elly?M?Hol Nicole?Heussen Johannes?Noth Franz-Werner?Schwaiger Andreas?B?Schmitt

Institution:	(1) Department of Neurology, University Medical School, Pauwelsstr.30, D-52074 Aachen, Germany;(2) Department of Biometry, University Medical School, Pauwelsstr.30, D-52074 Aachen, Germany;(3) Aurigon Life Science GmbH, Bahnhofstr. 9-15, D-82327 Tutzing, Germany;(4) Department of Biochemistry, University of Conneticut Health Center, 06030 Farmington, CT, USA;(5) Netherland Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands

Abstract:	Background Interruption of mature axons activates a cascade of events in neuronal cell bodies which leads to various outcomes from functional regeneration in the PNS to the failure of any significant regeneration in the CNS. One factor which seems to play an important role in the molecular programs after axotomy is the stearoyl Coenzyme A-desaturase-1 (SCD-1). This enzyme is needed for the conversion of stearate into oleate. Beside its role in membrane synthesis, oleate could act as a neurotrophic factor, involved in signal transduction pathways via activation of protein kinases C.

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