A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C |
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| Authors: | Yuan Fang Verhelst Steven H L Blum Galia Coussens Lisa M Bogyo Matthew |
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| Affiliation: | Department of Pathology, and Microbiology & Immunology, Stanford School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA. |
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| Abstract: | Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members. |
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