| 5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究 |
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| 引用本文： | 张培全,曾和平.5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究[J].有机化学,2008,28(6):1035-1039. |
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| 作者姓名： | 张培全 曾和平 |
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| 作者单位： | 华南理工大学化学科学学院功能分子研究所,广州,510641 |
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| 基金项目： | 国家自然科学基金，广东省科技厅科技计划 |
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| 摘 要： | 设计合成了5-2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉(5), 用IR, UV, 1H NMR, MS和元素分析确认其结构. 利用DPPH•法和噻唑蓝比色法(MTT法)分别测定了目标产物的抗氧化活性及调控鼠骨髓间质干细胞(MSCs)增殖的作用. 结果表明, 目标产物有较强的抗氧化活性, 在低浓度时对鼠骨髓间质干细胞有促进作用.
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| 关 键 词： | 5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉 抗氧化活性 骨髓间质干细胞 |
| 收稿时间： | 2007-9-11 |
| 修稿时间： | 2007年9月1日 |
Synthesis, Antioxidation Activity of 5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol and Its Induction Proliferation ofMesenchymal Stem Cells |
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| ZHANG,Pei-Quan,ZENG,He-Ping.Synthesis, Antioxidation Activity of 5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol and Its Induction Proliferation ofMesenchymal Stem Cells[J].Chinese Journal of Organic Chemistry,2008,28(6):1035-1039. |
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| Authors: | ZHANG Pei-Quan ZENG He-Ping |
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| Institution: | (Institute of Functional Molecules, Faculty of Chemistry, South China University of Technology, Guangzhou 510641) |
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| Abstract: | 5-2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol (5) was synthesized and character-ized by IR, UV, 1H NMR, MS spectra and elemental analysis. Meanwhile, the stem cell activity and antioxidation activity of the title compound were investigated by the MTT and DPPH• methods. From the result it can be seen that the title compound has strong antioxidation activity and can induce the proliferation of mesenchymal stem cell under a low concentration condition. |
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| Keywords: | 5-[2-(8-hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol antioxidation activity proliferation of mes-enchymal stem cell |
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