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Predicting olfactory receptor neuron responses from odorant structure |
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| Authors: | Michael Schmuker Marien de Bruyne Melanie Hähnel Gisbert Schneider |
| Institution: | 1. Johann Wolfgang Goethe Universit?t, Beilstein Endowed Chair for Cheminformatics, Institute of Organic Chemistry and Chemical Biology, Siesmayerstr. 70, Frankfurt am Main, 60323, Germany 4. Freie Universit?t Berlin, Institute of Biology-Neurobiology, K?nigin-Luise-Str. 28–30, 14195, Berlin, Germany 2. Freie Universit?t Berlin, Institute of Biology-Neurobiology, K?nigin-Luise-Str. 28–30, 14195, Berlin, Germany 3. Monash University, School of Biological Sciences, Wellington Road, 3800, Clayton, VIC, Australia |
| Abstract: | BackgroundOlfactory receptors work at the interface between the chemical world of volatile molecules and the perception of scent in the brain. Their main purpose is to translate chemical space into information that can be processed by neural circuits. Assuming that these receptors have evolved to cope with this task, the analysis of their coding strategy promises to yield valuable insight in how to encode chemical information in an efficient way. |
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