N-propargylic beta-enaminones: common intermediates for the synthesis of polysubstituted pyrroles and pyridines. |
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| Authors: | Sandro Cacchi Giancarlo Fabrizi Eleonora Filisti |
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| Affiliation: | Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi La Sapienza, P.le A. Moro 5, 00185, Rome, Italy. sandro.cacchi@uniroma1.it |
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| Abstract: | N-Propargylic beta-enaminones have been used as common intermediates for the synthesis of polysubstituted pyrroles and pyridines. Best results have been obtained using DMSO as solvent. In the presence of Cs(2)CO(3) N-propargylic beta-enaminones are cyclized to pyrroles in good to high yields, whereas omitting bases and using CuBr leads to the selective formation of pyridines. |
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