| 离子液体中用Heck反应合成2-取代萘烯丙醇化合物 |
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| 引用本文： | 裴文,沈忱,莫峻,许孝良. 离子液体中用Heck反应合成2-取代萘烯丙醇化合物[J]. 有机化学, 2007, 27(5): 653-655 |
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| 作者姓名： | 裴文 沈忱 莫峻 许孝良 |
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| 作者单位： | 浙江工业大学化学工程与材料学院,杭州,310014 |
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| 基金项目： | 国家自然科学基金（No.20572100）资助项目. |
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| 摘 要： | 利用Heck反应, 在离子液体、金属钯或镍、碱和膦配体反应体系中, 由卤代萘与烯丙醇反应, 制得了高收率和高选择性的2-取代萘烯丙醇化合物. 该方法原料便宜易得、操作简单、反应体系可循环使用. 并讨论了醋酸镍替代醋酸钯、不同膦配体、溶剂及碱对反应转化率的影响. 通过核磁共振、红外光谱、质谱和元素分析对产物的结构进行了表征.
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| 关 键 词： | Heck反应 离子液体 萘取代烯丙醇 合成 金属钯和镍试剂 |
| 收稿时间： | 2006-07-11 |
| 修稿时间： | 2006-07-11 |
Synthesis of 2-Substituted Naphthyl Allyl Alcohols byHeck Re-action in Ionic Liquids |
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| PEI Wen,SHEN Chen,MO Jun,XU Xiao-Liang. Synthesis of 2-Substituted Naphthyl Allyl Alcohols byHeck Re-action in Ionic Liquids[J]. Chinese Journal of Organic Chemistry, 2007, 27(5): 653-655 |
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| Authors: | PEI Wen SHEN Chen MO Jun XU Xiao-Liang |
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| Affiliation: | College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310014 |
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| Abstract: | 2-Substituted naphthyl allyl alcohols were prepared with high regioselectivity and high yield catalyzed by palladium or nickel catalyst in the presence of triethylamine as base and phosphines (Ph3P, DPPP, DPPE, DPPM and DPPB) as ligand in ionic liquid. The methodology has advantage of lower cost, simpler operation and wider diversity of raw material. The reaction medium system can be recycled and re-used. The reaction conditions were discussed and the product structure was characterized by 1H NMR and 13C NMR, IR, MS spectra and elemental analysis. |
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| Keywords: | Heck reaction ionic liquid substituted naphthyl allyl alcohol synthesis palladium or nickel catalyst |
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